Predicted to enable ribosome binding activity. Involved in calcium import into the mitochondrion; mitochondrial calcium ion homeostasis; and protein insertion into mitochondrial membrane. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:199,850,490–199,851,605 | 104.8 kb | Distal (>10kb) Multiome | 817 | |
| chr2:199,910,668–199,912,042 | 44.5 kb | Distal (>10kb) Multiome | 929 | |
| chr2:199,953,877–199,954,033 | 1.8 kb | Proximal (<10kb) | 17 | |
| chr2:199,955,094–199,956,570 | 233 bp | At TSS Multiome | 1078 | |
| chr2:200,090,238–200,091,621 | 135.5 kb | Distal (>10kb) Multiome | 66 | |
| chr2:200,201,704–200,202,415 | 246.2 kb | Distal (>10kb) Multiome | 128 | |
| chr2:200,203,430–200,204,082 | 247.9 kb | Distal (>10kb) Multiome | 141 | |
| chr2:200,481,420–200,481,868 | 525.7 kb | Distal (>10kb) Multiome HiCAR | 350 | |
| chr2:200,509,374–200,510,438 | 554.2 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr2:200,525,770–200,526,701 | 570.3 kb | Distal (>10kb) Multiome HiCAR | 869 | |
| chr2:200,585,716–200,586,842 | 630.3 kb | Distal (>10kb) Multiome HiCAR | 627 | |
| chr2:200,713,048–200,713,472 | 757.5 kb | Distal (>10kb) Multiome HiCAR | 763 | |
| chr2:200,810,854–200,812,782 | 855.8 kb | Distal (>10kb) Multiome HiCAR | 1048 |
Genomic view of the MAIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.