The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAGI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAGI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAGI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:78,578,555–78,579,400 | 192.2 kb | Distal (>10kb) Multiome | 177 | |
| chr7:78,769,490–78,769,856 | 1.3 kb | Proximal (<10kb) | 57 | |
| chr7:78,770,559–78,771,590 | 105 bp | At TSS Multiome | 212 | |
| chr7:78,775,182–78,776,038 | 4.1 kb | Proximal (<10kb) | 8 | |
| chr7:78,780,655–78,780,839 | 9.5 kb | Proximal (<10kb) | 67 |
Genomic view of the MAGI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.