MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAD2L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAD2L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAD2L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:119,627,005–119,629,431 | 437.9 kb | Distal (>10kb) Multiome HiCAR | 731 | |
| chr4:120,066,153–120,067,563 | 56 bp | At TSS Multiome | 906 | |
| chr4:120,067,811–120,068,290 | 953 bp | At TSS | 136 | |
| chr4:120,071,116–120,071,695 | 4.3 kb | Proximal (<10kb) | 75 | |
| chr4:120,921,437–120,923,278 | 856.0 kb | Distal (>10kb) Multiome HiCAR | 557 | |
| chr4:121,070,302–121,071,684 | 1004.5 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr4:121,252,291–121,253,003 | 1185.7 kb | Distal (>10kb) Multiome HiCAR | 155 |
Genomic view of the MAD2L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.