Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LYSMD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYSMD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYSMD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:99,100,255–99,100,873 | 632.8 kb | Distal (>10kb) Multiome HiCAR | 434 | |
| chr15:99,104,575–99,106,394 | 627.3 kb | Distal (>10kb) Multiome HiCAR | 760 | |
| chr15:99,250,788–99,251,976 | 482.0 kb | Distal (>10kb) Multiome HiCAR | 872 | |
| chr15:99,447,371–99,447,978 | 285.7 kb | Distal (>10kb) Multiome | 143 | |
| chr15:99,564,843–99,566,939 | 167.5 kb | Distal (>10kb) Multiome | 959 | |
| chr15:99,731,463–99,731,933 | 1.4 kb | Proximal (<10kb) | 117 | |
| chr15:99,732,722–99,734,404 | 159 bp | At TSS Multiome | 723 | |
| chr15:99,734,510–99,735,017 | 1.1 kb | Proximal (<10kb) | 19 | |
| chr15:99,735,140–99,735,631 | 1.8 kb | Proximal (<10kb) | 13 | |
| chr15:99,752,894–99,753,419 | 19.9 kb | Distal (>10kb) Multiome | 105 | |
| chr15:99,983,052–99,984,349 | 250.1 kb | Distal (>10kb) Multiome | 293 |
Genomic view of the LYSMD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.