Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LYRM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYRM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYRM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:89,352,138–89,353,410 | 286.0 kb | Distal (>10kb) Multiome | 882 | |
| chr6:89,411,134–89,412,806 | 226.8 kb | Distal (>10kb) Multiome HiCAR | 540 | |
| chr6:89,432,777–89,434,173 | 205.6 kb | Distal (>10kb) Multiome HiCAR | 524 | |
| chr6:89,483,120–89,483,667 | 155.3 kb | Distal (>10kb) Multiome | 199 | |
| chr6:89,493,449–89,494,745 | 144.6 kb | Distal (>10kb) Multiome | 266 | |
| chr6:89,496,006–89,496,706 | 142.4 kb | Distal (>10kb) Multiome | 166 | |
| chr6:89,522,599–89,523,543 | 115.7 kb | Distal (>10kb) Multiome | 138 | |
| chr6:89,588,903–89,590,722 | 48.5 kb | Distal (>10kb) Multiome | 245 | |
| chr6:89,638,049–89,639,180 | 39 bp | At TSS Multiome | 783 | |
| chr6:89,817,396–89,818,338 | 179.0 kb | Distal (>10kb) Multiome | 165 | |
| chr6:89,819,010–89,820,467 | 181.0 kb | Distal (>10kb) Multiome | 929 | |
| chr6:89,829,059–89,830,308 | 191.0 kb | Distal (>10kb) Multiome | 769 | |
| chr6:89,890,967–89,891,702 | 252.6 kb | Distal (>10kb) Multiome | 96 |
Genomic view of the LYRM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.