This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for LYPLA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYPLA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYPLA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:53,842,551–53,843,618 | 258.8 kb | Distal (>10kb) Multiome | 936 | |
| chr8:53,879,185–53,882,655 | 222.0 kb | Distal (>10kb) Multiome | 721 | |
| chr8:54,021,584–54,023,157 | 79.6 kb | Distal (>10kb) Multiome | 965 | |
| chr8:54,101,305–54,102,633 | 6 bp | At TSS Multiome | 744 | |
| chr8:54,134,624–54,135,508 | 33.2 kb | Distal (>10kb) Multiome | 807 | |
| chr8:54,223,881–54,225,934 | 123.1 kb | Distal (>10kb) Multiome | 303 | |
| chr8:54,259,099–54,260,380 | 158.1 kb | Distal (>10kb) Multiome | 139 | |
| chr8:54,267,801–54,269,212 | 166.5 kb | Distal (>10kb) Multiome | 253 | |
| chr8:54,300,265–54,301,003 | 198.8 kb | Distal (>10kb) Multiome | 195 | |
| chr8:54,301,815–54,302,560 | 200.3 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the LYPLA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.