This gene encodes a protein that contains a leucine zipper motif. The exact function of the encoded protein is not known. In mice this gene affects neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for LUZP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LUZP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LUZP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:22,976,445–22,976,936 | 192.2 kb | Distal (>10kb) Multiome | 351 | |
| chr1:23,019,210–23,020,140 | 149.4 kb | Distal (>10kb) Multiome | 1023 | |
| chr1:23,167,347–23,168,292 | 524 bp | At TSS | 489 | |
| chr1:23,168,432–23,169,217 | 14 bp | At TSS Multiome | 673 | |
| chr1:23,177,510–23,178,128 | 9.0 kb | Proximal (<10kb) Multiome | 628 | |
| chr1:23,216,791–23,217,828 | 48.2 kb | Distal (>10kb) Multiome | 415 | |
| chr1:23,343,731–23,344,999 | 175.7 kb | Distal (>10kb) Multiome | 939 | |
| chr1:23,367,863–23,369,864 | 199.6 kb | Distal (>10kb) Multiome | 1018 | |
| chr1:23,370,752–23,371,596 | 202.3 kb | Distal (>10kb) Multiome | 344 | |
| chr1:23,403,774–23,404,231 | 235.2 kb | Distal (>10kb) Multiome | 536 | |
| chr1:23,436,460–23,437,402 | 268.0 kb | Distal (>10kb) Multiome | 248 |
Genomic view of the LUZP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.