This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for LSG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LSG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LSG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:194,383,090–194,383,793 | 288.8 kb | Distal (>10kb) Multiome | 74 | |
| chr3:194,485,977–194,488,163 | 185.2 kb | Distal (>10kb) Multiome | 767 | |
| chr3:194,583,635–194,584,305 | 88.2 kb | Distal (>10kb) Multiome | 872 | |
| chr3:194,632,897–194,634,022 | 38.7 kb | Distal (>10kb) Multiome | 802 | |
| chr3:194,672,083–194,672,732 | 217 bp | At TSS Multiome | 910 | |
| chr3:194,682,618–194,683,090 | 10.5 kb | Distal (>10kb) Multiome | 506 | |
| chr3:194,685,606–194,686,409 | 13.7 kb | Distal (>10kb) Multiome | 691 | |
| chr3:194,686,697–194,688,545 | 15.6 kb | Distal (>10kb) Multiome | 426 | |
| chr3:194,768,696–194,769,693 | 97.1 kb | Distal (>10kb) Multiome | 375 | |
| chr3:195,106,453–195,106,932 | 434.4 kb | Distal (>10kb) Multiome HiCAR | 491 | |
| chr3:195,117,791–195,118,489 | 446.0 kb | Distal (>10kb) Multiome HiCAR | 327 | |
| chr3:195,259,295–195,260,886 | 588.1 kb | Distal (>10kb) Multiome HiCAR | 943 |
Genomic view of the LSG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.