Involved in regulation of presynapse assembly. Acts upstream of or within positive regulation of amyloid-beta formation. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRTM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRTM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRTM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:66,917,225–66,917,431 | 8.6 kb | Proximal (<10kb) | 26 | |
| chr10:66,925,085–66,925,227 | 807 bp | At TSS | 19 | |
| chr10:66,925,720–66,926,213 | 4 bp | At TSS Multiome | 268 | |
| chr10:66,926,444–66,926,574 | 409 bp | At TSS | 58 | |
| chr10:66,926,918–66,927,077 | 883 bp | At TSS | 5 | |
| chr10:66,927,933–66,928,627 | 1.9 kb | Proximal (<10kb) | 106 | |
| chr10:66,931,284–66,931,658 | 5.2 kb | Proximal (<10kb) | 126 |
Genomic view of the LRRTM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.