Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC58. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC58 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC58, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:120,093,804–120,096,088 | 254.5 kb | Distal (>10kb) Multiome | 1114 | |
| chr3:120,284,858–120,285,627 | 64.1 kb | Distal (>10kb) Multiome | 237 | |
| chr3:120,341,531–120,342,143 | 7.2 kb | Proximal (<10kb) | 68 | |
| chr3:120,348,500–120,350,077 | 139 bp | At TSS Multiome | 1003 | |
| chr3:120,416,932–120,417,959 | 68.1 kb | Distal (>10kb) Multiome | 482 | |
| chr3:120,450,045–120,452,154 | 101.7 kb | Distal (>10kb) Multiome | 496 | |
| chr3:120,558,699–120,560,290 | 209.7 kb | Distal (>10kb) Multiome | 654 | |
| chr3:120,595,704–120,596,910 | 247.0 kb | Distal (>10kb) Multiome | 683 | |
| chr3:120,604,594–120,605,753 | 255.9 kb | Distal (>10kb) Multiome | 62 | |
| chr3:120,622,775–120,623,611 | 273.8 kb | Distal (>10kb) Multiome | 221 |
Genomic view of the LRRC58 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.