NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for LRRC4C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC4C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC4C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:40,293,097–40,294,754 | 1165.5 kb | Distal (>10kb) Multiome | 419 | |
| chr11:41,274,477–41,275,244 | 184.6 kb | Distal (>10kb) Multiome | 72 | |
| chr11:41,449,328–41,449,770 | 9.9 kb | Proximal (<10kb) | 20 | |
| chr11:41,456,164–41,456,575 | 3.1 kb | Proximal (<10kb) | 20 | |
| chr11:41,459,886–41,460,241 | 250 bp | At TSS | 38 | |
| chr11:42,406,995–42,407,990 | 947.9 kb | Distal (>10kb) Multiome HiCAR | 148 | |
| chr11:43,130,136–43,131,188 | 1671.1 kb | Distal (>10kb) Multiome HiCAR | 99 | |
| chr11:43,311,481–43,312,563 | 1852.3 kb | Distal (>10kb) Multiome HiCAR | 920 |
Genomic view of the LRRC4C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.