Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:99,014,449–99,015,990 | 236.4 kb | Distal (>10kb) Multiome | 669 | |
| chr15:99,058,502–99,059,907 | 192.2 kb | Distal (>10kb) Multiome | 515 | |
| chr15:99,100,255–99,100,873 | 150.7 kb | Distal (>10kb) Multiome | 434 | |
| chr15:99,104,575–99,106,394 | 146.3 kb | Distal (>10kb) Multiome | 760 | |
| chr15:99,153,040–99,153,478 | 98.1 kb | Distal (>10kb) Multiome | 52 | |
| chr15:99,249,324–99,249,780 | 1.6 kb | Proximal (<10kb) | 271 | |
| chr15:99,250,788–99,251,976 | 26 bp | At TSS Multiome | 872 | |
| chr15:99,402,101–99,402,755 | 151.1 kb | Distal (>10kb) Multiome | 160 | |
| chr15:99,447,371–99,447,978 | 196.3 kb | Distal (>10kb) Multiome | 143 | |
| chr15:99,732,722–99,734,404 | 482.2 kb | Distal (>10kb) Multiome HiCAR | 723 | |
| chr15:99,752,894–99,753,419 | 501.9 kb | Distal (>10kb) Multiome HiCAR | 105 |
Genomic view of the LRRC28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.