This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for LRP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:46,664,502–46,665,016 | 253.8 kb | Distal (>10kb) Multiome | 126 | |
| chr11:46,674,791–46,675,556 | 243.5 kb | Distal (>10kb) Multiome | 308 | |
| chr11:46,700,262–46,701,275 | 217.9 kb | Distal (>10kb) Multiome | 997 | |
| chr11:46,826,562–46,827,053 | 91.7 kb | Distal (>10kb) Multiome | 529 | |
| chr11:46,845,538–46,846,680 | 72.4 kb | Distal (>10kb) Multiome | 879 | |
| chr11:46,912,540–46,913,271 | 5.8 kb | Proximal (<10kb) Multiome | 252 | |
| chr11:46,916,824–46,917,034 | 1.6 kb | Proximal (<10kb) | 250 | |
| chr11:46,917,991–46,919,090 | 103 bp | At TSS Multiome | 405 | |
| chr11:46,919,948–46,920,142 | 1.3 kb | Proximal (<10kb) | 207 | |
| chr11:46,936,572–46,937,187 | 18.1 kb | Distal (>10kb) Multiome | 744 | |
| chr11:46,947,422–46,947,958 | 29.2 kb | Distal (>10kb) Multiome | 150 | |
| chr11:47,160,949–47,161,864 | 242.9 kb | Distal (>10kb) Multiome HiCAR | 322 | |
| chr11:47,176,472–47,177,856 | 258.4 kb | Distal (>10kb) Multiome HiCAR | 857 | |
| chr11:47,184,866–47,187,095 | 267.9 kb | Distal (>10kb) Multiome | 849 | |
| chr11:47,214,114–47,215,529 | 296.2 kb | Distal (>10kb) Multiome | 785 |
Genomic view of the LRP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.