Transcription factors with Perturb-seq knockdown data for LRIG3-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRIG3-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRIG3-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:58,915,675–58,916,035 | 4.6 kb | Proximal (<10kb) | 115 | |
| chr12:58,916,902–58,917,025 | 3.6 kb | Proximal (<10kb) | 66 | |
| chr12:58,919,255–58,920,781 | 114 bp | At TSS Multiome | 754 | |
| chr12:58,922,716–58,924,329 | 2.7 kb | Proximal (<10kb) Multiome | 252 | |
| chr12:58,924,758–58,926,054 | 4.7 kb | Proximal (<10kb) Multiome | 329 | |
| chr12:58,949,852–58,950,996 | 29.9 kb | Distal (>10kb) Multiome | 153 | |
| chr12:59,074,983–59,076,039 | 154.9 kb | Distal (>10kb) Multiome HiCAR | 168 |
Genomic view of the LRIG3-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.