Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRIG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRIG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRIG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:66,220,628–66,221,378 | 280.1 kb | Distal (>10kb) Multiome | 818 | |
| chr3:66,415,883–66,417,138 | 84.3 kb | Distal (>10kb) Multiome | 115 | |
| chr3:66,441,917–66,443,468 | 58.6 kb | Distal (>10kb) Multiome | 428 | |
| chr3:66,452,752–66,454,355 | 47.1 kb | Distal (>10kb) Multiome | 257 | |
| chr3:66,495,710–66,496,011 | 5.0 kb | Proximal (<10kb) | 113 | |
| chr3:66,499,991–66,502,058 | 186 bp | At TSS Multiome | 746 | |
| chr3:66,506,693–66,507,165 | 5.7 kb | Proximal (<10kb) | 9 | |
| chr3:66,532,082–66,532,601 | 31.3 kb | Distal (>10kb) Multiome | 186 | |
| chr3:66,533,829–66,534,908 | 33.5 kb | Distal (>10kb) Multiome | 120 | |
| chr3:66,572,847–66,573,861 | 72.4 kb | Distal (>10kb) Multiome | 150 | |
| chr3:66,615,610–66,616,183 | 114.8 kb | Distal (>10kb) Multiome | 133 | |
| chr3:66,798,002–66,798,599 | 297.3 kb | Distal (>10kb) Multiome | 198 | |
| chr3:66,817,999–66,819,661 | 317.5 kb | Distal (>10kb) Multiome HiCAR | 178 |
Genomic view of the LRIG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.