This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LPAR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPAR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPAR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:84,620,449–84,621,260 | 272.3 kb | Distal (>10kb) Multiome | 711 | |
| chr1:84,689,823–84,691,321 | 202.7 kb | Distal (>10kb) Multiome | 784 | |
| chr1:84,882,868–84,883,419 | 9.8 kb | Proximal (<10kb) | 18 | |
| chr1:84,892,367–84,893,746 | 42 bp | At TSS Multiome | 406 | |
| chr1:84,894,500–84,895,091 | 1.3 kb | Proximal (<10kb) | 117 | |
| chr1:84,944,592–84,945,445 | 51.8 kb | Distal (>10kb) Multiome | 438 | |
| chr1:84,996,442–84,998,604 | 104.0 kb | Distal (>10kb) Multiome | 490 | |
| chr1:85,047,243–85,049,064 | 155.0 kb | Distal (>10kb) Multiome | 533 | |
| chr1:85,061,692–85,062,785 | 169.0 kb | Distal (>10kb) Multiome | 384 |
Genomic view of the LPAR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.