This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for LMO4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMO4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMO4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:87,131,612–87,132,886 | 196.9 kb | Distal (>10kb) Multiome | 494 | |
| chr1:87,133,487–87,134,387 | 194.9 kb | Distal (>10kb) Multiome | 138 | |
| chr1:87,151,430–87,152,405 | 176.8 kb | Distal (>10kb) Multiome | 383 | |
| chr1:87,326,049–87,326,461 | 2.4 kb | Proximal (<10kb) | 160 | |
| chr1:87,327,650–87,329,684 | 391 bp | At TSS Multiome | 766 | |
| chr1:87,330,197–87,332,371 | 2.7 kb | Proximal (<10kb) Multiome | 698 | |
| chr1:87,334,099–87,335,778 | 5.8 kb | Proximal (<10kb) Multiome | 560 | |
| chr1:87,472,778–87,473,867 | 144.6 kb | Distal (>10kb) Multiome | 236 |
Genomic view of the LMO4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.