Transcription factors with Perturb-seq knockdown data for LINC01162. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01162 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01162, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:20,653,525–20,654,195 | 181.5 kb | Distal (>10kb) Multiome | 116 | |
| chr7:20,700,321–20,701,121 | 134.6 kb | Distal (>10kb) Multiome | 96 | |
| chr7:20,775,903–20,777,464 | 58.7 kb | Distal (>10kb) Multiome | 266 | |
| chr7:20,777,629–20,779,374 | 57.1 kb | Distal (>10kb) Multiome | 442 | |
| chr7:20,786,445–20,787,645 | 48.4 kb | Distal (>10kb) Multiome | 550 | |
| chr7:20,787,761–20,788,275 | 47.3 kb | Distal (>10kb) Multiome | 79 | |
| chr7:20,797,161–20,799,274 | 37.2 kb | Distal (>10kb) Multiome | 595 | |
| chr7:20,826,301–20,826,836 | 8.5 kb | Proximal (<10kb) | 40 | |
| chr7:20,832,067–20,832,276 | 3.1 kb | Proximal (<10kb) | 31 | |
| chr7:20,834,800–20,834,946 | 428 bp | At TSS | 45 | |
| chr7:20,835,207–20,835,672 | at TSS | At TSS | 126 | |
| chr7:21,116,901–21,118,389 | 282.7 kb | Distal (>10kb) Multiome | 124 | |
| chr7:21,771,740–21,772,441 | 936.8 kb | Distal (>10kb) Multiome HiCAR | 259 |
Genomic view of the LINC01162 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.