Transcription factors with Perturb-seq knockdown data for LINC00698. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00698 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00698, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:62,873,372–62,875,535 | 76.4 kb | Distal (>10kb) Multiome | 412 | |
| chr3:62,941,101–62,941,300 | 9.1 kb | Proximal (<10kb) | 65 | |
| chr3:62,951,077–62,951,446 | 648 bp | At TSS | 91 | |
| chr3:62,955,232–62,955,450 | 4.8 kb | Proximal (<10kb) | 21 |
Genomic view of the LINC00698 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.