Transcription factors with Perturb-seq knockdown data for LINC00630. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00630 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00630, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:102,516,273–102,517,096 | 252.4 kb | Distal (>10kb) Multiome | 197 | |
| chrX:102,599,050–102,600,172 | 169.7 kb | Distal (>10kb) Multiome | 573 | |
| chrX:102,651,041–102,651,962 | 117.7 kb | Distal (>10kb) Multiome | 96 | |
| chrX:102,712,007–102,713,630 | 56.7 kb | Distal (>10kb) Multiome | 188 | |
| chrX:102,745,604–102,746,582 | 23.2 kb | Distal (>10kb) Multiome | 103 | |
| chrX:102,768,555–102,769,457 | 79 bp | At TSS Multiome | 420 |
Genomic view of the LINC00630 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.