Transcription factors with Perturb-seq knockdown data for LINC00467. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00467 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00467, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:210,373,253–210,375,038 | 1008.5 kb | Distal (>10kb) Multiome HiCAR | 933 | |
| chr1:211,133,108–211,134,829 | 248.5 kb | Distal (>10kb) Multiome | 739 | |
| chr1:211,222,016–211,223,252 | 160.1 kb | Distal (>10kb) Multiome | 343 | |
| chr1:211,258,333–211,261,113 | 123.5 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:211,326,284–211,327,905 | 55.9 kb | Distal (>10kb) Multiome | 543 | |
| chr1:211,375,133–211,375,818 | 7.3 kb | Proximal (<10kb) Multiome | 107 | |
| chr1:211,377,645–211,377,841 | 4.9 kb | Proximal (<10kb) | 40 | |
| chr1:211,382,531–211,383,307 | 60 bp | At TSS Multiome | 921 | |
| chr1:211,398,188–211,399,458 | 16.1 kb | Distal (>10kb) Multiome | 128 | |
| chr1:211,399,597–211,400,219 | 17.4 kb | Distal (>10kb) Multiome | 80 | |
| chr1:211,416,272–211,417,162 | 33.9 kb | Distal (>10kb) Multiome | 257 | |
| chr1:211,469,768–211,470,490 | 87.5 kb | Distal (>10kb) Multiome HiCAR | 383 | |
| chr1:211,513,158–211,514,512 | 131.4 kb | Distal (>10kb) Multiome HiCAR | 484 | |
| chr1:211,515,159–211,516,023 | 132.9 kb | Distal (>10kb) Multiome HiCAR | 818 | |
| chr1:211,577,546–211,580,066 | 196.6 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:211,630,152–211,630,733 | 247.7 kb | Distal (>10kb) Multiome | 515 | |
| chr1:211,655,045–211,655,900 | 272.7 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr1:211,667,030–211,667,875 | 284.7 kb | Distal (>10kb) Multiome | 301 | |
| chr1:211,675,193–211,676,330 | 293.1 kb | Distal (>10kb) Multiome | 936 |
Genomic view of the LINC00467 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.