Transcription factors with Perturb-seq knockdown data for LINC00466. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC00466 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC00466, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:63,316,605–63,317,949 | at TSS | At TSS | 584 | |
| chr1:63,319,478–63,320,003 | 2.3 kb | Proximal (<10kb) | 118 | |
| chr1:63,320,118–63,320,808 | 2.9 kb | Proximal (<10kb) | 76 | |
| chr1:63,321,080–63,321,448 | 3.9 kb | Proximal (<10kb) | 51 | |
| chr1:63,321,551–63,321,712 | 4.3 kb | Proximal (<10kb) | 44 | |
| chr1:63,321,880–63,324,736 | 4.7 kb | Proximal (<10kb) | 684 | |
| chr1:63,326,144–63,327,160 | 8.9 kb | Proximal (<10kb) | 213 |
Genomic view of the LINC00466 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.