LHX8

LIM homeobox 8 | Lhx7

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Biological processes 16 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)forebrain neuron development (GO:0021884)neuron differentiation (GO:0030182)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)response to ethanol (GO:0045471)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating LHX8 0 TFs

Transcription factors with Perturb-seq knockdown data for LHX8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LHX8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LHX8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LHX8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:75,124,347–75,125,401	9.0 kb	Proximal (<10kb)	143
chr1:75,127,900–75,128,460	5.9 kb	Proximal (<10kb)	28
chr1:75,129,490–75,131,873	2.5 kb	Proximal (<10kb)	209
chr1:75,132,114–75,132,725	1.7 kb	Proximal (<10kb)	52
chr1:75,133,083–75,133,477	909 bp	At TSS	40
chr1:75,133,645–75,137,727	at TSS	At TSS	495

Genome Browser

Genomic view of the LHX8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.