TFs regulating LGALSL-DT 0 TFs

Transcription factors with Perturb-seq knockdown data for LGALSL-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LGALSL-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LGALSL-DT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LGALSL-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:64,227,941–64,228,667	225.6 kb	Distal (>10kb) Multiome	493
chr2:64,251,480–64,252,200	202.3 kb	Distal (>10kb) Multiome	104
chr2:64,252,396–64,252,854	201.2 kb	Distal (>10kb) Multiome	93
chr2:64,276,376–64,277,307	177.2 kb	Distal (>10kb) Multiome	252
chr2:64,330,958–64,331,642	122.7 kb	Distal (>10kb) Multiome	275
chr2:64,404,071–64,404,983	49.5 kb	Distal (>10kb) Multiome	340
chr2:64,453,131–64,455,109	324 bp	At TSS Multiome	767
chr2:64,459,486–64,459,967	5.5 kb	Proximal (<10kb)	89
chr2:64,460,283–64,460,894	6.3 kb	Proximal (<10kb)	57
chr2:64,523,863–64,525,127	70.4 kb	Distal (>10kb) Multiome	964
chr2:64,608,995–64,609,973	155.5 kb	Distal (>10kb) Multiome	430
chr2:64,644,172–64,645,396	191.2 kb	Distal (>10kb) Multiome	716
chr2:64,653,208–64,654,885	200.0 kb	Distal (>10kb) Multiome	978
chr2:64,750,029–64,752,111	297.2 kb	Distal (>10kb) Multiome	1065

Genome Browser

Genomic view of the LGALSL-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.