Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LGALSL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LGALSL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LGALSL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:64,227,941–64,228,667 | 226.1 kb | Distal (>10kb) Multiome | 493 | |
| chr2:64,251,480–64,252,200 | 202.8 kb | Distal (>10kb) Multiome | 104 | |
| chr2:64,252,396–64,252,854 | 201.7 kb | Distal (>10kb) Multiome | 93 | |
| chr2:64,276,376–64,277,307 | 177.7 kb | Distal (>10kb) Multiome | 252 | |
| chr2:64,330,958–64,331,642 | 123.2 kb | Distal (>10kb) Multiome | 275 | |
| chr2:64,404,071–64,404,983 | 50.0 kb | Distal (>10kb) Multiome | 340 | |
| chr2:64,453,131–64,455,109 | 155 bp | At TSS Multiome | 767 | |
| chr2:64,459,486–64,459,967 | 5.0 kb | Proximal (<10kb) | 89 | |
| chr2:64,460,283–64,460,894 | 5.8 kb | Proximal (<10kb) | 57 | |
| chr2:64,523,863–64,525,127 | 69.9 kb | Distal (>10kb) Multiome | 964 | |
| chr2:64,608,995–64,609,973 | 155.0 kb | Distal (>10kb) Multiome | 430 | |
| chr2:64,644,172–64,645,396 | 190.8 kb | Distal (>10kb) Multiome | 716 | |
| chr2:64,653,208–64,654,885 | 199.5 kb | Distal (>10kb) Multiome | 978 | |
| chr2:64,750,029–64,752,111 | 296.7 kb | Distal (>10kb) Multiome | 1065 |
Genomic view of the LGALSL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.