This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for LEMD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LEMD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LEMD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:33,547,185–33,548,324 | 241.4 kb | Distal (>10kb) Multiome | 155 | |
| chr6:33,570,899–33,571,638 | 217.7 kb | Distal (>10kb) Multiome | 755 | |
| chr6:33,579,935–33,580,700 | 208.8 kb | Distal (>10kb) Multiome | 639 | |
| chr6:33,592,764–33,593,449 | 196.2 kb | Distal (>10kb) Multiome | 224 | |
| chr6:33,620,828–33,622,474 | 167.1 kb | Distal (>10kb) Multiome | 594 | |
| chr6:33,632,607–33,634,721 | 156.5 kb | Distal (>10kb) Multiome | 600 | |
| chr6:33,711,017–33,712,173 | 77.4 kb | Distal (>10kb) Multiome | 943 | |
| chr6:33,771,283–33,772,101 | 17.4 kb | Distal (>10kb) Multiome | 478 | |
| chr6:33,788,007–33,789,360 | 47 bp | At TSS Multiome | 999 | |
| chr6:33,828,845–33,829,529 | 39.8 kb | Distal (>10kb) Multiome | 97 | |
| chr6:33,950,527–33,951,235 | 161.7 kb | Distal (>10kb) Multiome | 82 | |
| chr6:34,052,159–34,053,582 | 264.1 kb | Distal (>10kb) Multiome HiCAR | 133 | |
| chr6:34,056,249–34,056,753 | 267.4 kb | Distal (>10kb) Multiome HiCAR | 192 | |
| chr6:34,143,812–34,144,483 | 355.1 kb | Distal (>10kb) Multiome HiCAR | 304 | |
| chr6:34,144,948–34,146,170 | 356.5 kb | Distal (>10kb) Multiome HiCAR | 310 |
Genomic view of the LEMD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.