This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for LEF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LEF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LEF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:107,930,814–107,932,445 | 235.1 kb | Distal (>10kb) Multiome | 716 | |
| chr4:107,989,250–107,990,853 | 176.9 kb | Distal (>10kb) Multiome | 836 | |
| chr4:108,135,343–108,136,048 | 31.1 kb | Distal (>10kb) Multiome | 249 | |
| chr4:108,160,821–108,161,152 | 5.6 kb | Proximal (<10kb) | 64 | |
| chr4:108,166,123–108,169,630 | 2.2 kb | Proximal (<10kb) Multiome | 688 | |
| chr4:108,170,727–108,171,044 | 4.0 kb | Proximal (<10kb) | 120 | |
| chr4:108,171,178–108,173,760 | 4.5 kb | Proximal (<10kb) | 615 |
Genomic view of the LEF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.