Predicted to enable amyloid-beta binding activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to act upstream of or within regulation of protein processing. Predicted to be located in endomembrane system and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LDLRAD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LDLRAD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LDLRAD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:35,662,341–35,663,428 | 281.2 kb | Distal (>10kb) Multiome | 1145 | |
| chr11:35,821,506–35,822,608 | 122.0 kb | Distal (>10kb) Multiome | 433 | |
| chr11:35,943,391–35,943,566 | 494 bp | At TSS | 42 | |
| chr11:35,943,672–35,944,947 | 110 bp | At TSS Multiome | 502 | |
| chr11:35,946,637–35,947,106 | 2.6 kb | Proximal (<10kb) | 32 | |
| chr11:36,048,242–36,049,115 | 104.5 kb | Distal (>10kb) Multiome | 152 | |
| chr11:36,104,718–36,105,753 | 161.1 kb | Distal (>10kb) Multiome | 417 | |
| chr11:36,109,822–36,110,461 | 166.1 kb | Distal (>10kb) Multiome | 185 |
Genomic view of the LDLRAD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.