Involved in negative regulation of DNA-templated transcription; positive regulation of DNA-templated transcription; and regulation of MAPK cascade. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LBH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LBH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LBH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:30,146,037–30,148,505 | 84.8 kb | Distal (>10kb) Multiome | 973 | |
| chr2:30,191,616–30,192,270 | 39.5 kb | Distal (>10kb) Multiome | 256 | |
| chr2:30,224,965–30,225,311 | 6.2 kb | Proximal (<10kb) | 152 | |
| chr2:30,230,493–30,233,101 | 931 bp | At TSS Multiome | 678 | |
| chr2:30,234,085–30,234,824 | 2.6 kb | Proximal (<10kb) | 217 | |
| chr2:30,239,337–30,239,552 | 7.8 kb | Proximal (<10kb) | 223 | |
| chr2:30,240,468–30,240,641 | 8.9 kb | Proximal (<10kb) | 44 | |
| chr2:30,290,483–30,291,069 | 59.3 kb | Distal (>10kb) Multiome | 341 | |
| chr2:30,334,726–30,336,025 | 103.7 kb | Distal (>10kb) Multiome | 296 | |
| chr2:30,446,921–30,447,966 | 215.8 kb | Distal (>10kb) Multiome HiCAR | 993 |
Genomic view of the LBH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.