Enables mRNA 3'-UTR binding activity and poly(A) binding activity. Involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Located in cytoplasmic stress granule and cytosolic small ribosomal subunit. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LARP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:50,110,765–50,112,744 | 288.9 kb | Distal (>10kb) Multiome | 967 | |
| chr12:50,166,692–50,167,931 | 233.4 kb | Distal (>10kb) Multiome | 812 | |
| chr12:50,232,842–50,233,291 | 167.8 kb | Distal (>10kb) Multiome | 105 | |
| chr12:50,283,141–50,284,081 | 117.3 kb | Distal (>10kb) Multiome | 750 | |
| chr12:50,396,563–50,396,913 | 4.0 kb | Proximal (<10kb) | 242 | |
| chr12:50,398,996–50,399,281 | 1.6 kb | Proximal (<10kb) | 10 | |
| chr12:50,400,518–50,401,658 | 24 bp | At TSS Multiome | 948 | |
| chr12:50,504,583–50,505,803 | 104.1 kb | Distal (>10kb) Multiome | 806 |
Genomic view of the LARP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.