LAPTM4B
lysosomal protein transmembrane 4 beta | LC27

Enables ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including endosome transport via multivesicular body sorting pathway; negative regulation of macromolecule metabolic process; and regulation of lysosomal membrane permeability. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.1 Developmental clusters: GC6
Biological processes 30 terms
cell projection (GO:0042995)ceramide binding (GO:0097001)early endosome (GO:0005769)endomembrane system (GO:0012505)endosome (GO:0005768)endosome (GO:0005768)endosome membrane (GO:0010008)endosome organization (GO:0007032)endosome transport via multivesicular body sorting pathway (GO:0032509)kinase binding (GO:0019900)late endosome membrane (GO:0031902)late endosome membrane (GO:0031902)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosome (GO:0005764)membrane (GO:0016020)multivesicular body membrane (GO:0032585)multivesicular body membrane (GO:0032585)multivesicular body, internal vesicle (GO:0097487)negative regulation of lysosomal protein catabolic process (GO:1905166)negative regulation of transforming growth factor beta1 production (GO:0032911)phosphatidylinositol bisphosphate binding (GO:1902936)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)regulation of lysosomal membrane permeability (GO:0097213)regulation of lysosomal membrane permeability (GO:0097213)regulation of lysosome organization (GO:1905671)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
LAPTM4B — as a Regulated Gene

TFs regulating LAPTM4B 0 TFs

Transcription factors with Perturb-seq knockdown data for LAPTM4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAPTM4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to LAPTM4B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAPTM4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr8:97,643,510–97,645,718 131.7 kb Distal (>10kb) Multiome 951
chr8:97,761,283–97,761,890 14.1 kb Distal (>10kb) Multiome 88
chr8:97,774,820–97,776,789 92 bp At TSS Multiome 1013
chr8:97,777,927–97,778,143 2.1 kb Proximal (<10kb) 352
chr8:97,778,238–97,780,015 2.9 kb Proximal (<10kb) Multiome 400
chr8:97,781,217–97,781,811 5.4 kb Proximal (<10kb) 58
chr8:97,781,999–97,784,345 7.8 kb Proximal (<10kb) Multiome 298
chr8:97,868,488–97,870,075 93.6 kb Distal (>10kb) Multiome 498
chr8:97,932,331–97,934,476 158.0 kb Distal (>10kb) Multiome 228
chr8:98,011,075–98,011,541 235.4 kb Distal (>10kb) Multiome 178
chr8:98,045,232–98,046,414 269.9 kb Distal (>10kb) Multiome 829
chr8:98,064,246–98,065,195 289.0 kb Distal (>10kb) Multiome 385

Genome Browser

Genomic view of the LAPTM4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr8:97,633,510 – 98,075,195
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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