This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LAPTM4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAPTM4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAPTM4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:19,863,073–19,864,223 | 188.0 kb | Distal (>10kb) Multiome | 720 | |
| chr2:19,868,540–19,869,572 | 182.7 kb | Distal (>10kb) Multiome | 302 | |
| chr2:19,901,191–19,902,460 | 149.8 kb | Distal (>10kb) Multiome | 1066 | |
| chr2:19,989,520–19,990,653 | 61.5 kb | Distal (>10kb) Multiome | 924 | |
| chr2:20,011,873–20,013,148 | 39.0 kb | Distal (>10kb) Multiome | 585 | |
| chr2:20,042,508–20,043,544 | 8.1 kb | Proximal (<10kb) | 34 | |
| chr2:20,045,819–20,046,308 | 5.3 kb | Proximal (<10kb) | 74 | |
| chr2:20,049,101–20,049,530 | 2.1 kb | Proximal (<10kb) | 46 | |
| chr2:20,050,661–20,052,578 | 300 bp | At TSS Multiome | 1029 | |
| chr2:20,097,914–20,098,555 | 46.8 kb | Distal (>10kb) Multiome | 480 | |
| chr2:20,106,361–20,107,468 | 55.3 kb | Distal (>10kb) Multiome | 181 | |
| chr2:20,207,998–20,208,855 | 156.7 kb | Distal (>10kb) Multiome | 346 | |
| chr2:20,223,290–20,226,136 | 172.0 kb | Distal (>10kb) Multiome | 1023 | |
| chr2:20,242,059–20,243,494 | 190.9 kb | Distal (>10kb) Multiome | 372 | |
| chr2:20,350,092–20,352,594 | 299.3 kb | Distal (>10kb) Multiome | 1127 |
Genomic view of the LAPTM4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.