Predicted to enable single-stranded RNA binding activity. Predicted to be involved in retrotransposition. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for L1TD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = L1TD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of L1TD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:62,089,820–62,090,452 | 104.6 kb | Distal (>10kb) Multiome | 107 | |
| chr1:62,177,448–62,178,351 | 17.0 kb | Distal (>10kb) Multiome | 70 | |
| chr1:62,194,263–62,195,303 | 123 bp | At TSS Multiome | 231 | |
| chr1:62,196,179–62,196,706 | 1.3 kb | Proximal (<10kb) | 51 | |
| chr1:62,198,057–62,199,070 | 3.6 kb | Proximal (<10kb) Multiome | 351 | |
| chr1:62,286,714–62,287,329 | 92.1 kb | Distal (>10kb) Multiome | 188 | |
| chr1:62,318,171–62,319,540 | 124.2 kb | Distal (>10kb) Multiome | 432 | |
| chr1:62,327,423–62,328,065 | 132.8 kb | Distal (>10kb) Multiome | 254 | |
| chr1:62,435,836–62,437,694 | 241.7 kb | Distal (>10kb) Multiome | 1064 |
Genomic view of the L1TD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.