This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KRT10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRT10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRT10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,615,478–40,615,916 | 206.9 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr17:40,637,853–40,638,362 | 184.5 kb | Distal (>10kb) Multiome | 83 | |
| chr17:40,735,202–40,736,205 | 87.0 kb | Distal (>10kb) Multiome | 21 | |
| chr17:40,818,771–40,819,228 | 3.4 kb | Proximal (<10kb) | 513 | |
| chr17:41,334,358–41,334,923 | 512.0 kb | Distal (>10kb) Multiome HiCAR | 60 | |
| chr17:41,527,111–41,529,407 | 705.8 kb | Distal (>10kb) Multiome HiCAR | 635 | |
| chr17:41,529,883–41,531,145 | 707.9 kb | Distal (>10kb) Multiome HiCAR | 504 | |
| chr17:41,548,740–41,549,518 | 726.5 kb | Distal (>10kb) Multiome HiCAR | 698 | |
| chr17:41,647,765–41,648,495 | 825.4 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr17:41,662,549–41,663,015 | 840.2 kb | Distal (>10kb) Multiome HiCAR | 643 | |
| chr17:41,665,564–41,667,291 | 844.6 kb | Distal (>10kb) Multiome HiCAR | 883 |
Genomic view of the KRT10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.