The protein encoded by this gene is a nucleolar protein that interacts with zinc finger 106 protein. The encoded protein has several of the same characteristics as nucleostemin and may be involved in testis development. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for KNOP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KNOP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KNOP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:19,487,848–19,488,641 | 230.0 kb | Distal (>10kb) Multiome | 340 | |
| chr16:19,521,532–19,522,649 | 196.0 kb | Distal (>10kb) Multiome | 825 | |
| chr16:19,523,702–19,524,351 | 194.2 kb | Distal (>10kb) Multiome | 765 | |
| chr16:19,555,060–19,556,522 | 162.6 kb | Distal (>10kb) Multiome | 1001 | |
| chr16:19,717,856–19,718,929 | 148 bp | At TSS Multiome | 935 | |
| chr16:19,722,929–19,723,622 | 5.1 kb | Proximal (<10kb) Multiome | 66 | |
| chr16:19,853,872–19,854,881 | 136.3 kb | Distal (>10kb) Multiome | 59 | |
| chr16:19,884,718–19,885,614 | 166.8 kb | Distal (>10kb) Multiome HiCAR | 352 |
Genomic view of the KNOP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.