KLHL7

kelch like family member 7 | KLHL6, RP42, SBBI26

This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]

Member of: DE-10 Developmental clusters: GC5

Biological processes 18 terms

Cul3-RING ubiquitin ligase complex (GO:0031463)Cul3-RING ubiquitin ligase complex (GO:0031463)Cul3-RING ubiquitin ligase complex (GO:0031463)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)identical protein binding (GO:0042802)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)

Expression (TPM)

TFs regulating KLHL7 0 TFs

Transcription factors with Perturb-seq knockdown data for KLHL7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KLHL7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:22,549,622–22,550,567	555.5 kb	Distal (>10kb) Multiome HiCAR	336
chr7:22,822,496–22,823,057	282.9 kb	Distal (>10kb) Multiome	671
chr7:22,853,488–22,855,243	251.5 kb	Distal (>10kb) Multiome	941
chr7:22,937,587–22,938,683	167.5 kb	Distal (>10kb) Multiome	139
chr7:23,013,184–23,014,464	91.6 kb	Distal (>10kb) Multiome	751
chr7:23,105,409–23,106,715	16 bp	At TSS Multiome	833
chr7:23,116,020–23,116,472	10.4 kb	Distal (>10kb) Multiome	105
chr7:23,181,578–23,182,460	76.2 kb	Distal (>10kb) Multiome	935
chr7:23,205,915–23,206,590	100.5 kb	Distal (>10kb) Multiome	154
chr7:23,247,362–23,248,065	142.0 kb	Distal (>10kb) Multiome	202
chr7:23,299,105–23,299,994	193.6 kb	Distal (>10kb) Multiome	852

Genome Browser

Genomic view of the KLHL7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.