Enables ubiquitin-like ligase-substrate adaptor activity. Involved in rescue of stalled ribosome and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin ligase complex and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHDC10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHDC10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHDC10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:129,775,743–129,776,961 | 294.0 kb | Distal (>10kb) Multiome | 77 | |
| chr7:129,778,637–129,782,868 | 290.2 kb | Distal (>10kb) Multiome | 821 | |
| chr7:129,824,642–129,826,481 | 244.7 kb | Distal (>10kb) Multiome | 809 | |
| chr7:129,829,901–129,830,704 | 240.3 kb | Distal (>10kb) Multiome | 440 | |
| chr7:129,914,750–129,915,367 | 155.4 kb | Distal (>10kb) Multiome | 82 | |
| chr7:129,948,898–129,950,017 | 121.4 kb | Distal (>10kb) Multiome | 747 | |
| chr7:129,952,295–129,953,395 | 117.6 kb | Distal (>10kb) Multiome | 834 | |
| chr7:130,069,977–130,071,012 | 148 bp | At TSS Multiome | 873 | |
| chr7:130,072,210–130,072,448 | 1.7 kb | Proximal (<10kb) | 318 | |
| chr7:130,140,676–130,141,967 | 71.1 kb | Distal (>10kb) Multiome HiCAR | 371 | |
| chr7:130,204,919–130,205,826 | 134.9 kb | Distal (>10kb) Multiome | 874 | |
| chr7:130,272,868–130,273,649 | 202.9 kb | Distal (>10kb) Multiome | 220 | |
| chr7:130,485,879–130,487,031 | 415.8 kb | Distal (>10kb) Multiome HiCAR | 696 | |
| chr7:130,733,079–130,734,492 | 663.3 kb | Distal (>10kb) Multiome HiCAR | 383 |
Genomic view of the KLHDC10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.