KIFC1

kinesin family member C1 | HSET, KNSL2

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and minus-end-directed microtubule motor activity. Involved in mitotic metaphase chromosome alignment and mitotic spindle assembly. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-11 DE-11.1

Biological processes 26 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)centrosome (GO:0005813)cytoplasm (GO:0005737)early endosome (GO:0005769)kinesin complex (GO:0005871)membrane (GO:0016020)microtubule (GO:0005874)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule motor activity (GO:0003777)microtubule motor activity (GO:0003777)microtubule motor activity (GO:0003777)microtubule organizing center (GO:0005815)microtubule-based movement (GO:0007018)microtubule-based movement (GO:0007018)mitotic metaphase chromosome alignment (GO:0007080)mitotic sister chromatid segregation (GO:0000070)mitotic spindle (GO:0072686)mitotic spindle assembly (GO:0090307)mitotic spindle assembly (GO:0090307)nucleus (GO:0005634)nucleus (GO:0005634)spermatogenesis (GO:0007283)spindle (GO:0005819)

Expression (TPM)

TFs regulating KIFC1 0 TFs

Transcription factors with Perturb-seq knockdown data for KIFC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIFC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KIFC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIFC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:33,161,505–33,162,100	230.1 kb	Distal (>10kb) Multiome	589
chr6:33,199,801–33,201,289	191.2 kb	Distal (>10kb) Multiome	1049
chr6:33,204,263–33,205,422	187.2 kb	Distal (>10kb) Multiome	762
chr6:33,208,069–33,208,990	183.2 kb	Distal (>10kb) Multiome	858
chr6:33,248,132–33,249,983	143.5 kb	Distal (>10kb) Multiome	961
chr6:33,271,370–33,272,508	119.9 kb	Distal (>10kb) Multiome	1058
chr6:33,276,685–33,277,905	114.4 kb	Distal (>10kb) Multiome	807
chr6:33,288,941–33,289,881	102.4 kb	Distal (>10kb) Multiome	701
chr6:33,297,445–33,300,232	94.0 kb	Distal (>10kb) Multiome	1095
chr6:33,312,436–33,314,207	78.9 kb	Distal (>10kb) Multiome	795
chr6:33,317,189–33,318,504	73.9 kb	Distal (>10kb) Multiome	649
chr6:33,322,636–33,323,832	68.7 kb	Distal (>10kb) Multiome	941
chr6:33,346,609–33,347,126	45.0 kb	Distal (>10kb) Multiome	37
chr6:33,390,888–33,392,247	213 bp	At TSS Multiome	993
chr6:33,409,936–33,411,502	18.7 kb	Distal (>10kb) Multiome	977
chr6:33,417,606–33,419,249	26.4 kb	Distal (>10kb) Multiome	973
chr6:33,419,793–33,420,532	28.4 kb	Distal (>10kb) Multiome	162
chr6:33,425,590–33,426,362	34.1 kb	Distal (>10kb) Multiome	665
chr6:33,431,024–33,432,096	39.4 kb	Distal (>10kb) Multiome	337
chr6:33,454,074–33,454,852	62.7 kb	Distal (>10kb) Multiome	906
chr6:33,547,185–33,548,324	155.9 kb	Distal (>10kb) Multiome	155
chr6:33,570,899–33,571,638	179.6 kb	Distal (>10kb) Multiome	755
chr6:33,579,935–33,580,700	188.5 kb	Distal (>10kb) Multiome	639
chr6:33,592,764–33,593,449	201.1 kb	Distal (>10kb) Multiome	224
chr6:33,620,828–33,622,474	230.2 kb	Distal (>10kb) Multiome	594
chr6:33,632,607–33,634,721	240.8 kb	Distal (>10kb) Multiome	600

Genome Browser

Genomic view of the KIFC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.