The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for KIF22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,594,581–29,595,807 | 195.3 kb | Distal (>10kb) Multiome | 486 | |
| chr16:29,613,063–29,614,058 | 177.0 kb | Distal (>10kb) Multiome | 302 | |
| chr16:29,614,664–29,615,288 | 175.7 kb | Distal (>10kb) Multiome | 247 | |
| chr16:29,666,524–29,667,045 | 124.0 kb | Distal (>10kb) Multiome | 338 | |
| chr16:29,678,867–29,679,831 | 111.5 kb | Distal (>10kb) Multiome | 783 | |
| chr16:29,708,839–29,709,431 | 81.7 kb | Distal (>10kb) Multiome | 96 | |
| chr16:29,709,743–29,710,091 | 80.7 kb | Distal (>10kb) Multiome | 21 | |
| chr16:29,784,957–29,785,426 | 5.5 kb | Proximal (<10kb) Multiome | 452 | |
| chr16:29,790,073–29,791,192 | 119 bp | At TSS Multiome | 1003 | |
| chr16:29,804,592–29,808,172 | 15.1 kb | Distal (>10kb) Multiome | 1275 | |
| chr16:29,810,746–29,812,649 | 21.6 kb | Distal (>10kb) Multiome | 826 | |
| chr16:29,815,828–29,817,186 | 25.4 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:29,862,597–29,863,901 | 72.7 kb | Distal (>10kb) Multiome | 953 | |
| chr16:29,876,281–29,878,282 | 86.9 kb | Distal (>10kb) Multiome | 319 | |
| chr16:29,899,174–29,900,833 | 108.8 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 135.5 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 171.2 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 183.0 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 205.4 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 230.8 kb | Distal (>10kb) Multiome | 764 | |
| chr16:30,052,803–30,053,364 | 262.4 kb | Distal (>10kb) Multiome | 989 | |
| chr16:30,063,722–30,066,296 | 273.3 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 285.2 kb | Distal (>10kb) Multiome | 828 |
Genomic view of the KIF22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.