KIF18B

kinesin family member 18B

Enables cytoskeletal motor activity and kinesin binding activity. Involved in microtubule depolymerization; mitotic cell cycle; and regulation of cell division. Located in cytosol; microtubule; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-11 DE-11.1

Biological processes 37 terms

ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)astral microtubule (GO:0000235)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeletal motor activity (GO:0003774)cytoskeletal motor activity (GO:0003774)cytoskeleton (GO:0005856)cytosol (GO:0005829)kinesin binding (GO:0019894)kinesin complex (GO:0005871)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule depolymerization (GO:0007019)microtubule depolymerization (GO:0007019)microtubule depolymerization (GO:0007019)microtubule end (GO:1990752)microtubule motor activity (GO:0003777)microtubule plus-end (GO:0035371)microtubule-based movement (GO:0007018)microtubule-based movement (GO:0007018)mitotic cell cycle (GO:0000278)mitotic cell cycle (GO:0000278)mitotic sister chromatid segregation (GO:0000070)mitotic spindle astral microtubule (GO:0061673)mitotic spindle midzone (GO:1990023)nuclear body (GO:0016604)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plus-end-directed microtubule motor activity (GO:0008574)protein binding (GO:0005515)regulation of cell division (GO:0051302)spindle microtubule (GO:0005876)

Expression (TPM)

TFs regulating KIF18B 0 TFs

Transcription factors with Perturb-seq knockdown data for KIF18B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF18B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KIF18B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF18B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:44,656,036–44,656,706	291.4 kb	Distal (>10kb) Multiome	280
chr17:44,689,325–44,690,416	257.9 kb	Distal (>10kb) Multiome	916
chr17:44,758,700–44,759,204	188.9 kb	Distal (>10kb) Multiome	167
chr17:44,774,509–44,776,365	173.0 kb	Distal (>10kb) Multiome	794
chr17:44,778,982–44,779,764	168.4 kb	Distal (>10kb) Multiome	595
chr17:44,829,525–44,830,482	117.6 kb	Distal (>10kb) Multiome	503
chr17:44,899,009–44,900,053	48.1 kb	Distal (>10kb) Multiome	987
chr17:44,911,165–44,911,786	36.3 kb	Distal (>10kb) Multiome	412
chr17:44,947,322–44,948,161	42 bp	At TSS Multiome	891
chr17:44,966,864–44,969,160	20.7 kb	Distal (>10kb) Multiome	526
chr17:44,987,181–44,987,616	39.8 kb	Distal (>10kb) Multiome	93
chr17:45,021,768–45,022,248	74.3 kb	Distal (>10kb) Multiome	739
chr17:45,051,210–45,051,755	103.8 kb	Distal (>10kb) Multiome	771
chr17:45,060,587–45,061,694	113.5 kb	Distal (>10kb) Multiome	979
chr17:45,131,590–45,133,655	185.6 kb	Distal (>10kb) Multiome	898
chr17:45,135,189–45,136,052	187.8 kb	Distal (>10kb) Multiome	930
chr17:45,143,207–45,145,183	196.1 kb	Distal (>10kb) Multiome	308
chr17:45,147,066–45,150,271	199.6 kb	Distal (>10kb) Multiome	1345
chr17:45,160,688–45,162,340	213.9 kb	Distal (>10kb) Multiome	1200
chr17:45,197,493–45,198,189	250.2 kb	Distal (>10kb) Multiome	835
chr17:45,241,380–45,242,217	294.1 kb	Distal (>10kb) Multiome	131
chr17:45,246,828–45,248,615	300.0 kb	Distal (>10kb) Multiome	858

Genome Browser

Genomic view of the KIF18B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.