This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KIF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:92,350,016–92,350,962 | 242.6 kb | Distal (>10kb) Multiome | 107 | |
| chr10:92,573,390–92,574,819 | 18.9 kb | Distal (>10kb) Multiome | 974 | |
| chr10:92,590,647–92,592,274 | 1.5 kb | Proximal (<10kb) Multiome | 830 | |
| chr10:92,592,537–92,593,580 | 16 bp | At TSS Multiome | 832 | |
| chr10:92,688,898–92,690,771 | 96.7 kb | Distal (>10kb) Multiome | 843 | |
| chr10:92,691,602–92,693,182 | 99.5 kb | Distal (>10kb) Multiome | 451 | |
| chr10:92,695,704–92,696,803 | 103.0 kb | Distal (>10kb) Multiome | 353 | |
| chr10:92,789,669–92,790,231 | 196.8 kb | Distal (>10kb) Multiome | 103 | |
| chr10:92,848,153–92,849,292 | 255.4 kb | Distal (>10kb) Multiome | 664 |
Genomic view of the KIF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.