This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for KIDINS220. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIDINS220 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIDINS220, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:8,582,837–8,584,915 | 253.6 kb | Distal (>10kb) Multiome | 618 | |
| chr2:8,677,675–8,679,558 | 158.7 kb | Distal (>10kb) Multiome | 902 | |
| chr2:8,680,827–8,683,692 | 155.7 kb | Distal (>10kb) Multiome | 1154 | |
| chr2:8,684,500–8,686,247 | 151.8 kb | Distal (>10kb) Multiome | 951 | |
| chr2:8,836,956–8,838,243 | 42 bp | At TSS Multiome | 738 | |
| chr2:8,896,416–8,897,439 | 59.3 kb | Distal (>10kb) Multiome | 153 | |
| chr2:9,002,394–9,004,716 | 166.3 kb | Distal (>10kb) Multiome | 676 | |
| chr2:9,074,800–9,075,347 | 237.4 kb | Distal (>10kb) Multiome | 123 | |
| chr2:9,095,563–9,096,416 | 258.3 kb | Distal (>10kb) Multiome | 192 | |
| chr2:9,110,578–9,111,244 | 273.4 kb | Distal (>10kb) Multiome | 147 |
Genomic view of the KIDINS220 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.