Enables histone demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Predicted to be involved in chromatin remodeling; midbrain development; and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for KDM7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KDM7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KDM7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:139,971,936–139,972,384 | 204.8 kb | Distal (>10kb) Multiome | 102 | |
| chr7:140,062,257–140,063,368 | 114.1 kb | Distal (>10kb) Multiome | 805 | |
| chr7:140,175,218–140,177,799 | 184 bp | At TSS Multiome | 1056 | |
| chr7:140,229,607–140,231,952 | 53.1 kb | Distal (>10kb) Multiome | 914 | |
| chr7:140,241,793–140,243,015 | 65.2 kb | Distal (>10kb) Multiome | 460 | |
| chr7:140,278,313–140,279,187 | 101.8 kb | Distal (>10kb) Multiome | 65 | |
| chr7:140,397,976–140,398,715 | 221.5 kb | Distal (>10kb) Multiome | 696 | |
| chr7:140,403,831–140,404,498 | 227.1 kb | Distal (>10kb) Multiome | 333 | |
| chr7:140,455,562–140,456,050 | 278.9 kb | Distal (>10kb) Multiome | 50 | |
| chr7:140,639,882–140,641,732 | 463.8 kb | Distal (>10kb) Multiome HiCAR | 486 |
Genomic view of the KDM7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.