This gene encodes a member of the potassium channel tetramerization-domain containing (KCTD) protein family. Members of this protein family regulate the biophysical characteristics of ion channels. In mouse, this protein interacts with hyperpolarization-activated cyclic nucleotide-gated channel complex 3 and enhances its cell surface expression and current density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for KCTD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:214,378,748–214,380,041 | 1187.7 kb | Distal (>10kb) Multiome HiCAR | 127 | |
| chr1:214,446,675–214,447,519 | 1120.2 kb | Distal (>10kb) Multiome HiCAR | 415 | |
| chr1:214,602,774–214,603,730 | 964.2 kb | Distal (>10kb) Multiome HiCAR | 887 | |
| chr1:214,683,504–214,684,332 | 883.5 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr1:215,566,760–215,568,510 | 143 bp | At TSS Multiome | 1008 | |
| chr1:215,569,150–215,569,756 | 1.8 kb | Proximal (<10kb) | 175 |
Genomic view of the KCTD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.