Transcription factors with Perturb-seq knockdown data for KCNMB2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNMB2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNMB2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:178,595,138–178,596,190 | 264.8 kb | Distal (>10kb) Multiome | 165 | |
| chr3:178,737,556–178,738,594 | 122.3 kb | Distal (>10kb) Multiome | 142 | |
| chr3:178,859,925–178,860,525 | at TSS | At TSS | 196 | |
| chr3:178,964,368–178,964,920 | 104.3 kb | Distal (>10kb) Multiome | 96 | |
| chr3:179,071,152–179,072,483 | 211.4 kb | Distal (>10kb) Multiome | 794 | |
| chr3:179,147,033–179,149,466 | 287.8 kb | Distal (>10kb) Multiome | 953 |
Genomic view of the KCNMB2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.