This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KCNK6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNK6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNK6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,043,611–38,044,643 | 276.0 kb | Distal (>10kb) Multiome | 66 | |
| chr19:38,074,116–38,074,898 | 245.3 kb | Distal (>10kb) Multiome | 299 | |
| chr19:38,183,265–38,183,970 | 136.2 kb | Distal (>10kb) Multiome | 156 | |
| chr19:38,223,967–38,224,571 | 95.5 kb | Distal (>10kb) Multiome | 677 | |
| chr19:38,229,570–38,230,021 | 90.0 kb | Distal (>10kb) Multiome | 354 | |
| chr19:38,255,918–38,256,778 | 63.3 kb | Distal (>10kb) Multiome | 371 | |
| chr19:38,263,873–38,265,423 | 55.3 kb | Distal (>10kb) Multiome HiCAR | 590 | |
| chr19:38,304,071–38,305,583 | 14.6 kb | Distal (>10kb) Multiome | 531 | |
| chr19:38,315,514–38,316,642 | 3.8 kb | Proximal (<10kb) Multiome | 747 | |
| chr19:38,319,279–38,320,342 | 73 bp | At TSS Multiome | 359 | |
| chr19:38,335,358–38,337,514 | 15.9 kb | Distal (>10kb) Multiome | 898 | |
| chr19:38,361,454–38,362,809 | 42.3 kb | Distal (>10kb) Multiome | 604 | |
| chr19:38,374,176–38,375,269 | 54.8 kb | Distal (>10kb) Multiome | 1041 | |
| chr19:38,385,485–38,386,937 | 66.1 kb | Distal (>10kb) Multiome | 156 | |
| chr19:38,387,065–38,389,471 | 68.3 kb | Distal (>10kb) Multiome | 591 | |
| chr19:38,394,369–38,395,035 | 74.8 kb | Distal (>10kb) Multiome | 191 | |
| chr19:38,402,504–38,403,738 | 83.2 kb | Distal (>10kb) Multiome | 940 | |
| chr19:38,417,766–38,418,568 | 98.3 kb | Distal (>10kb) Multiome | 407 | |
| chr19:38,434,539–38,435,128 | 115.0 kb | Distal (>10kb) Multiome | 238 | |
| chr19:38,452,620–38,453,510 | 133.3 kb | Distal (>10kb) Multiome | 355 | |
| chr19:38,506,710–38,507,745 | 187.4 kb | Distal (>10kb) Multiome | 369 | |
| chr19:38,514,956–38,515,568 | 195.4 kb | Distal (>10kb) Multiome | 404 | |
| chr19:38,565,090–38,565,701 | 245.5 kb | Distal (>10kb) Multiome | 164 | |
| chr19:38,595,857–38,597,322 | 276.6 kb | Distal (>10kb) Multiome | 478 | |
| chr19:38,617,752–38,619,569 | 299.2 kb | Distal (>10kb) Multiome | 835 |
Genomic view of the KCNK6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.