CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for KAT14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KAT14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KAT14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:17,938,730–17,940,231 | 198.7 kb | Distal (>10kb) Multiome | 678 | |
| chr20:17,968,085–17,969,639 | 169.0 kb | Distal (>10kb) Multiome | 1144 | |
| chr20:18,032,971–18,033,755 | 104.7 kb | Distal (>10kb) Multiome | 212 | |
| chr20:18,057,257–18,058,052 | 80.0 kb | Distal (>10kb) Multiome | 323 | |
| chr20:18,058,764–18,059,467 | 78.7 kb | Distal (>10kb) Multiome | 393 | |
| chr20:18,101,249–18,101,961 | 36.2 kb | Distal (>10kb) Multiome | 74 | |
| chr20:18,103,190–18,103,994 | 34.2 kb | Distal (>10kb) Multiome | 149 | |
| chr20:18,137,127–18,138,367 | 20 bp | At TSS Multiome | 1046 | |
| chr20:18,144,520–18,145,374 | 6.7 kb | Proximal (<10kb) | 259 | |
| chr20:18,287,674–18,288,982 | 150.5 kb | Distal (>10kb) Multiome | 971 | |
| chr20:18,413,071–18,413,534 | 275.5 kb | Distal (>10kb) Multiome | 167 |
Genomic view of the KAT14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.