Involved in regulation of mitochondrial transcription. Located in mitochondrion and nucleoplasm. Part of NSL complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KANSL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KANSL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KANSL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:96,507,900–96,508,563 | 130.1 kb | Distal (>10kb) Multiome | 466 | |
| chr2:96,509,253–96,509,998 | 128.7 kb | Distal (>10kb) Multiome | 525 | |
| chr2:96,531,989–96,532,491 | 106.1 kb | Distal (>10kb) Multiome | 500 | |
| chr2:96,536,180–96,538,128 | 101.6 kb | Distal (>10kb) Multiome | 684 | |
| chr2:96,538,413–96,539,012 | 99.5 kb | Distal (>10kb) Multiome | 371 | |
| chr2:96,554,285–96,554,861 | 83.7 kb | Distal (>10kb) Multiome | 435 | |
| chr2:96,637,810–96,638,901 | 21 bp | At TSS Multiome | 1144 | |
| chr2:96,642,571–96,642,984 | 4.3 kb | Proximal (<10kb) | 100 | |
| chr2:96,739,549–96,740,363 | 101.8 kb | Distal (>10kb) Multiome | 708 | |
| chr2:96,760,354–96,761,531 | 122.5 kb | Distal (>10kb) Multiome HiCAR | 776 | |
| chr2:96,762,598–96,764,653 | 124.8 kb | Distal (>10kb) Multiome HiCAR | 406 | |
| chr2:96,815,434–96,817,859 | 178.0 kb | Distal (>10kb) Multiome | 926 | |
| chr2:96,857,099–96,859,416 | 219.8 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:96,868,320–96,870,552 | 231.8 kb | Distal (>10kb) Multiome | 907 | |
| chr2:96,881,325–96,881,826 | 243.3 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the KANSL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.