Enables transcription coactivator activity. Contributes to histone acetyltransferase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including cytosol; microtubule organizing center; and nuclear speck. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for JADE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JADE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JADE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:128,560,580–128,561,830 | 248.4 kb | Distal (>10kb) Multiome HiCAR | 273 | |
| chr4:128,635,174–128,636,473 | 174.1 kb | Distal (>10kb) Multiome | 362 | |
| chr4:128,682,905–128,683,618 | 126.5 kb | Distal (>10kb) Multiome HiCAR | 102 | |
| chr4:128,775,591–128,776,653 | 33.6 kb | Distal (>10kb) Multiome | 82 | |
| chr4:128,802,742–128,803,879 | 6.7 kb | Proximal (<10kb) Multiome | 154 | |
| chr4:128,809,374–128,810,275 | 13 bp | At TSS Multiome | 764 | |
| chr4:128,810,520–128,812,873 | 2.5 kb | Proximal (<10kb) Multiome | 1012 | |
| chr4:128,815,048–128,815,262 | 5.3 kb | Proximal (<10kb) | 12 | |
| chr4:128,830,823–128,832,500 | 22.1 kb | Distal (>10kb) Multiome | 300 | |
| chr4:128,866,342–128,867,421 | 57.2 kb | Distal (>10kb) Multiome HiCAR | 129 | |
| chr4:129,093,021–129,094,152 | 283.9 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the JADE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.