Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type catalytic step 1 spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ISY1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ISY1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ISY1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,878,828–128,880,293 | 281.5 kb | Distal (>10kb) Multiome | 1016 | |
| chr3:128,993,367–128,994,455 | 167.0 kb | Distal (>10kb) Multiome | 344 | |
| chr3:129,027,026–129,027,525 | 133.8 kb | Distal (>10kb) Multiome | 589 | |
| chr3:129,045,697–129,046,752 | 114.5 kb | Distal (>10kb) Multiome | 170 | |
| chr3:129,120,244–129,122,947 | 39.0 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,160,815–129,162,244 | 321 bp | At TSS Multiome | 917 | |
| chr3:129,183,284–129,184,525 | 22.9 kb | Distal (>10kb) Multiome | 966 | |
| chr3:129,249,227–129,250,064 | 88.5 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,278,315–129,279,976 | 117.8 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,305,525–129,306,095 | 144.8 kb | Distal (>10kb) Multiome | 342 | |
| chr3:129,314,154–129,316,995 | 153.9 kb | Distal (>10kb) Multiome | 949 | |
| chr3:129,343,720–129,344,497 | 183.0 kb | Distal (>10kb) Multiome | 346 | |
| chr3:129,344,512–129,344,822 | 183.6 kb | Distal (>10kb) Multiome | 58 | |
| chr3:129,359,825–129,360,642 | 199.4 kb | Distal (>10kb) Multiome | 65 | |
| chr3:129,399,193–129,399,868 | 238.5 kb | Distal (>10kb) Multiome | 625 | |
| chr3:129,428,173–129,429,050 | 267.6 kb | Distal (>10kb) Multiome | 504 | |
| chr3:129,439,426–129,440,695 | 279.1 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the ISY1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.